Water → HCID 19735046、化合物

HRID 326719ノート

反応式

HRID 326719 の反応式
[C:1]([CH:3]([CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)[C:4]([O:6]CC)=[O:5])#[N:2].[OH-].[Na+].O>C(O)C>[C:1]([CH:3]([CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)[C:4]([OH:6])=[O:5])#[N:2]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 19735035HCID 19735035、化合物

生成物 1

HCID 19735046HCID 19735046、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 2-cyano-3-(3-indolyl)propionate (350 mg, 1.45 mmol) (S. Masanori, et al., Heterocycles, 1981, 16: 941-9) was dissolved in ethanol (6 mL). 2N Sodium hydroxide solution (4 mL) was added and the reaction mixture was stirred at ambient temperature for 20 hours. Water (10 mL) was added and the ethanol was removed under reduced pressure. The pH of the aqueous solution was adjusted to approximately 1 with 6N hydrochloric acid solution and it was extracted with ethyl acetate. The ethyl acetate solution was concentrated in vacuo to give the title compound which was carried on to the next step without purification.

後処理

  1. customthe ethanol was removed under reduced pressure
  2. extractionwas extracted with ethyl acetate
  3. concentrationThe ethyl acetate solution was concentrated in vacuo

出典と根拠

ORDレコード
ord-2c93d15d301a4b138cb05278f29b4e5f
出典データセット
uspto-grants-1993_12
特許番号
US05270302

反応ノート

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