Cyclopropanemethanamine → 2-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acid

HRID 32673

反応式

HRID 32673 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](=[O:15])(=[O:14])[NH:12][CH3:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl[C:17]1C=CC(S(O)=O)=[CH:22][C:18]=1C(O)=O.C1(CN)CC1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](=[O:15])(=[O:14])[NH:12][CH2:13][CH:22]2[CH2:18][CH2:17]2)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

4

反応物 3

HCID 75646CyclopropanemethanamineHCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 151129042-Chloro-5-sulfino-benzoic acid

生成物 1

HCID 290355802-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acid収率 81%

実験手順

The title compound was synthesised according to the procedure described for 2-Chloro-5-methylsulfamoyl-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and cyclopropylmethylamine and obtained in 81% yield. MS (m/e): 288.0 (MH−, 100%).

後処理

  1. customobtained in 81% yield

出典と根拠

ORDレコード
ord-fc1203deeb0949a888ece709f3315086
出典データセット
uspto-grants-2008_09
特許番号
US07427612B2

関連ノート

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