Pyrrolidine → 5-Ethanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

反応式

[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].Cl[C:20]1C=CC(S(CC)(=O)=O)=CC=1C(O)=O.N1CCCC1>>[CH2:1]([S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3])[CH3:20]

参加物

反応物 3

HCID 31268Pyrrolidine

HCID 431409922-Chloro-5-(ethanesulfonyl)benzoic acid

HCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

生成物 1

HCID 597936105-Ethanesulfonyl-2-pyrrolidin-1-yl-benzoic acid収率 73%

実験手順

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(ethane-2-sulfonyl)-benzoic acid and pyrrolidine and obtained in 73% yield. MS (m/e): 282.2 (MH−, 100%).

後処理

customobtained in 73% yield

出典と根拠

ORDレコード: ord-58d8adca7bc6478cad019a701cff58c2
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07427612B2

反応ノート

読み込み中…