Ethyl Acetate → 2-[(2,2,2-Trifluoroethoxy)methyl]-4(3H)-pteridinone

HRID 326849

反応式

HRID 326849 の反応式
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[N:3]=1.C(OCC)(=[O:21])C>[OH-].[Na+]>[F:16][C:15]([F:18])([F:17])[CH2:14][O:13][CH2:12][C:4]1[NH:3][C:2](=[O:21])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=1

参加物

4

反応物 2

HCID 8857Ethyl AcetateHCID 105391874-Amino-2-[(2,2,2-trifluoroethoxy)methyl]pteridine

生成物 1

HCID 1354172242-[(2,2,2-Trifluoroethoxy)methyl]-4(3H)-pteridinone

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

Obtained using the procedure described in section d of Example 2, starting with 5.0 g (0.0193 mole) of 4-amino-2-[(2,2,2-trifluoroethoxy)methyl]pteridine in 105 ml of 5% aqueous sodium hydroxide. Heating time: 1 hour 30 minutes at 80° C. Yld: 2.5 g (50%), m.p. 165°-167° C. (ethyl acetate).

後処理

  1. customObtained
  2. temperatureHeating time
  3. custom1 hour 30 minutes
  4. customat 80° C

出典と根拠

ORDレコード
ord-45bbbca9bbf049fd95e47657fcfd4123
出典データセット
uspto-grants-1993_12
特許番号
US05270465

関連ノート

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