Sodium Hydroxide → 2-[(4-Methoxyphenoxy)methyl]-4(3H)-pteridinone

HRID 326858ノート

反応式

HRID 326858 の反応式
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[N:3]=1.[OH-:22].[Na+]>>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH2:12][C:4]2[NH:3][C:2](=[O:22])[C:11]3[C:6](=[N:7][CH:8]=[CH:9][N:10]=3)[N:5]=2)=[CH:15][CH:16]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 10731668HCID 10731668、化合物

生成物 1

HCID 1355138312-[(4-Methoxyphenoxy)methyl]-4(3H)-pteridinone

実験手順

Obtained using the procedure described in section b of Example 9, starting with 5.5 g (0.0194 mole) of 4-amino-2-[(4-methoxyphenoxy)methyl]pteridine in 150 ml of 5% aqueous sodium hydroxide. The solid obtained is taken up in dilute sodium hydroxide for purification. The insoluble portion is removed by filtration. The filtrate is acidified with acetic acid to pH 5.5. The precipitate formed is isolated by filtration; it is finally recrystallized from a mixture of ethanol and N,N-dimethylformamide. Yld: 1.7 g (31%), m.p. 233°-234° C.

後処理

  1. customObtained
  2. customThe solid obtained
  3. customis taken up in dilute sodium hydroxide for purification
  4. customThe insoluble portion is removed by filtration
  5. customThe precipitate formed
  6. customis isolated by filtration
  7. customit is finally recrystallized from a mixture of ethanol and N,N-dimethylformamide

出典と根拠

ORDレコード
ord-baa9b70f9bb24e1f9ccd219261d9caf6
出典データセット
uspto-grants-1993_12
特許番号
US05270465

反応ノート

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