4-Amino-2-[(4-methylphenoxy)methyl]pteridine → 2-[(4-Methylphenoxy)methyl]-4(3H)-pteridinone

HRID 326860

反応式

HRID 326860 の反応式
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[N:3]=1.C([OH:23])C.CN(C)C=O>[OH-].[Na+]>[CH3:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH2:12][C:4]2[NH:3][C:2](=[O:23])[C:11]3[C:6](=[N:7][CH:8]=[CH:9][N:10]=3)[N:5]=2)=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 105878894-Amino-2-[(4-methylphenoxy)methyl]pteridineHCID 19794673N,N-dimethylformamide ethanol

生成物 1

HCID 1355296872-[(4-Methylphenoxy)methyl]-4(3H)-pteridinone

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

Obtained using the procedure described in section b of Example 9, starting with 2.5 g (0.0094 mole) of 4-amino-2-[(4-methylphenoxy)methyl]pteridine in 68.1 ml of 5% aqueous sodium hydroxide. Heating time: 3 hours 15 minutes at 85° C. Yld: 1.3 g (52%), m.p. 232°-233° C. (ethanol/N,N-dimethylformamide).

後処理

  1. customObtained
  2. temperatureHeating time
  3. custom3 hours 15 minutes
  4. customat 85° C

出典と根拠

ORDレコード
ord-ad8ad30c5f5d4742890464ebfa0b1d46
出典データセット
uspto-grants-1993_12
特許番号
US05270465

関連ノート

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