2,5-Dichloro-3-nitrobenzoic acid → 2,5-Dichloro-3-nitrobenzoyl chloride

反応式

[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:17])=O>>[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:3]=1[C:4]([Cl:17])=[O:5]

参加物

反応物 2

HCID 69512,5-Dichloro-3-nitrobenzoic acid

HCID 24386Thionyl Chloride

生成物 1

HCID 101063862,5-Dichloro-3-nitrobenzoyl chloride収率 87.5%

実験手順

A mixture of 5.0 parts of 2,5-dichloro-3-nitrobenzoic acid and 16.2 parts of thionyl chloride was refluxed for 24 hours under argon. The reaction mixture was evaporated, yielding 4.74 parts (87.5%) of 2,5-dichloro-3-nitrobenzoyl chloride (interm. 66).

後処理

temperaturewas refluxed for 24 hours under argon
customThe reaction mixture was evaporated

出典と根拠

ORDレコード: ord-01de6a420dea4a1badd1e85d603c8351
出典データセット: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05270464

反応ノート

読み込み中…

参加物