Hydrochloric Acid → 4-Pentyl-3-cyclohexen-1-methanol toluenesulfonate

HRID 326959ノート

反応式

HRID 326959 の反応式
[CH2:1]([C:6]1[CH2:11][CH2:10][CH:9]([CH2:12][OH:13])[CH2:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[C:14]1(C)[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1.Cl.N1C=CC=C[CH:27]=1>>[C:16]1([CH3:27])[C:17]([S:20]([O:13][CH2:12][CH:9]2[CH2:10][CH2:11][C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:7][CH2:8]2)(=[O:21])=[O:22])=[CH:18][CH:19]=[CH:14][CH:15]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 197340354-Pentyl-3-cyclohexen-1-methanol

生成物 1

HCID 197340424-Pentyl-3-cyclohexen-1-methanol toluenesulfonate

実験手順

To a solution of 4-pentyl-3-cyclohexen-1-methanol (3.0 g) in pyridine (3.3 ml) at 0° C. was added p-toluenesulfonyl chloride (3.3 g). The reaction was stirred in an ice bath for 2 hours, and then stored at -20 ° C. for a further 16 hours. The reaction mixture was then poured into 2 M HCl (75 ml) and extracted with ethyl acetate. The combined organic layers were extracted with saturated sodium chloride and dried over sodium sulfate. The solvent was removed in vacuo to produce 4-pentyl-3-cyclohexen-1-methanol toluenesulfonate.

後処理

  1. waitstored at -20 ° C. for a further 16 hours
  2. extractionextracted with ethyl acetate
  3. extractionThe combined organic layers were extracted with saturated sodium chloride
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-ae801b14e8a045ceb9b70ec58a74af77
出典データセット
uspto-grants-1993_12
特許番号
US05271864

反応ノート

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