Ethyl 2,3-dihydro-1H-inden-2-ylcarbamate → N-Methylindan-2-amine
反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]1[NH:16][C:17](OCC)=O>O1CCCC1>[CH3:17][NH:16][CH:8]1[CH2:9][C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:7]1参加物
4
実験手順
To a suspension of 1.13 g (30 mmol) of anhydrous lithium aluminium hydride in 150 ml of tetrahydrofuran was added a solution of 2.2 g of ethyl indan-2-carbamate in 50 ml of the same solvent. The mixture was heated to reflux, allowed to cool, hydrolysed with an excess of aqueous 1N sodium hydroxide solution, and the mixture was filtered, concentrated and distilled at about 100 Pa at 150° C. 3.5 g of oil were obtained.
後処理
- temperatureThe mixture was heated
- temperatureto reflux
- temperatureto cool
- filtrationhydrolysed with an excess of aqueous 1N sodium hydroxide solution, and the mixture was filtered
- concentrationconcentrated
- distillationdistilled at about 100 Pa at 150° C
出典と根拠
- ORDレコード
- ord-1fdb0a3978964cd2bd6416b403c87dec
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05272157
反応ノート
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