Acetaminophen → Acetamide, N-[4-(2-quinolinylmethoxy)phenyl]-

HRID 327222ノート

反応式

HRID 327222 の反応式
Cl.Cl[CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1.[C:14]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)(=[O:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:14]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:3][C:4]2[CH:13]=[CH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=2)=[CH:20][CH:19]=1)(=[O:16])[CH3:15]

参加物

5

反応物 3

HCID 1983AcetaminophenHCID 11430Potassium CarbonateHCID 30838232-(Chloromethyl)quinoline hydrochloride

生成物 1

HCID 2747568Acetamide, N-[4-(2-quinolinylmethoxy)phenyl]-

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture containing 2-(chloromethyl)-quinoline hydrochloride (100.0 g), 4-acetamidophenol (70.69 g) and milled anhydrous potassium carbonate (194 g) was stirred in DMF (1.2 L) using a mechanical stirrer for 48 hours. The mixture was carefully poured onto ice/water (3 L) with vigourous stirring. After the ice had melted, the solid was filtered and rinsed thoroughly with water. It was recrystallized from 95% ethanol and filtered to give the title compound in three crops.

後処理

  1. customfor 48 hours
  2. additionThe mixture was carefully poured onto ice/water (3 L) with vigourous stirring
  3. filtrationthe solid was filtered
  4. washrinsed thoroughly with water
  5. customIt was recrystallized from 95% ethanol
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-b6d1ebc627634f50978ef9dd59c833e0
出典データセット
uspto-grants-1993_12
特許番号
US05272145

反応ノート

読み込み中…