Sodium Hydroxide → 2,3-Dihydro-5-[1-oxo-3-(piperidin-4-yl)propyl]benzofuran

HRID 327404ノート

反応式

HRID 327404 の反応式
C([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([C:14]2[CH:15]=[CH:16][C:17]3[O:21][CH2:20][CH2:19][C:18]=3[CH:22]=2)=[O:13])[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>Cl>[O:13]=[C:12]([C:14]1[CH:15]=[CH:16][C:17]2[O:21][CH2:20][CH2:19][C:18]=2[CH:22]=1)[CH2:11][CH2:10][CH:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 191084645-[3-(1-Acetylpiperidin-4-yl)-1-oxopropyl]-2,3-dihydrobenzofuran

生成物 1

HCID 191084552,3-Dihydro-5-[1-oxo-3-(piperidin-4-yl)propyl]benzofuran収率 100.2%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

To 30 ml of concentrated hydrochloric acid was added 5.00 g of 5-[3-(1-acetylpiperidin-4-yl)-1-oxopropyl]-2,3-dihydrobenzofuran, and the mixture was refluxed for 14 hours. The reaction mixture was left standing for cooling and then made basic with a dilute aqueous solution of sodium hydroxide, followed by extraction with methylene chloride. Organic layers were combined and dried over anhydrous sodium sulfate, then the solvent was distilled off to leave 4.31 g (100%) of 2,3-dihydro-5-[1-oxo-3-(piperidin-4-yl)propyl]benzofuran (4). The solid matter thus obtained was dissolved in methanol, treated with hydrogen chloride and recrystallized from methanol--ethyl acetate to give colorless needles, m.p. 203°-205° C. (decomp.)

後処理

  1. temperaturethe mixture was refluxed for 14 hours
  2. waitThe reaction mixture was left
  3. temperaturefor cooling
  4. extractionfollowed by extraction with methylene chloride
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-851d009da0a8402bbcee7025bacdf664
出典データセット
uspto-grants-1993_12
特許番号
US05273974

反応ノート

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