HCID 19108658、化合物 → HCID 19108657、化合物

HRID 327424ノート

反応式

HRID 327424 の反応式
[CH3:1][N:2]([NH:4][C:5]([C:7]1[N:8]([CH3:15])[CH:9]=[C:10]([N+:12]([O-])=O)[N:11]=1)=[O:6])[CH3:3]>CO.[Pd]>[CH3:3][N:2]([NH:4][C:5]([C:7]1[N:8]([CH3:15])[CH:9]=[C:10]([NH2:12])[N:11]=1)=[O:6])[CH3:1]

参加物

4

反応物 1

HCID 19108658HCID 19108658、化合物

生成物 1

HCID 19108657HCID 19108657、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A suspension of N-(N',N'-dimethylamino)-1-methyl-4-nitroimidazole-2-carboxamide (2.01 g, 9.4 mmol) and 5% Pd on charcoal (0.8 g) in chilled methanol (100 mL) was purged of air and hydrogenated at room temperature and atmospheric pressure for 4 hours. The catalyst was removed by filtration and the solvent was evaporated under reduced pressure to give N-(N',N'-dimethylamino)-1-methyl-4-aminoimidazole-2-carboxamide as a glassy solid which is unstable and used directly in the next step.

後処理

  1. customwas purged of air and hydrogenated at room temperature
  2. customThe catalyst was removed by filtration
  3. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-67b5adc0a58f430583acd561c3c1cb17
出典データセット
uspto-grants-1993_12
特許番号
US05273991

反応ノート

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