Formic Acid → 4-Methylbenzimidazole

HRID 327444

反応式

HRID 327444 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[NH2:9].[CH:10](O)=O>>[CH3:1][C:2]1[C:3]2[N:9]=[CH:10][NH:8][C:4]=2[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 284Formic AcidHCID 175932,3-Diaminotoluene

生成物 1

HCID 15193414-Methylbenzimidazole収率 90%

反応条件

温度
70 °C

実験手順

A mixture of 3-methyl-1,2-benzenediamine (11.9 g) and formic acid (150 mL) was heated at 70° C. for 15 minutes. The solvent was removed under reduced pressure and the residual oil was stirred with water (100 mL) and sodium hydroxide solution (65 mL of 4.0 N) was added until the solution was just basic. The precipitate was filtered off, washed with water, and air dried to give 11.6 g (90%) of 4-methyl-1H-benzimidazole, mp 141°-145° C.

後処理

  1. customThe solvent was removed under reduced pressure
  2. additionwas added until the solution
  3. filtrationThe precipitate was filtered off
  4. washwashed with water, and air
  5. customdried

出典と根拠

ORDレコード
ord-3592da26c31349c4ad925e57eefe2413
出典データセット
uspto-grants-1993_12
特許番号
US05273975

関連ノート

読み込み中…