Chlorosulfonic acid → 5-(Chlorosulfonyl)-2,3-difluorobenzoic acid

HRID 32749

反応式

HRID 32749 の反応式
[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:12][S:13](O)(=[O:15])=[O:14]>>[Cl:12][S:13]([C:8]1[CH:9]=[C:10]([F:11])[C:2]([F:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5])(=[O:15])=[O:14]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 3705902,3-Difluorobenzoic acid

生成物 1

HCID 509984745-(Chlorosulfonyl)-2,3-difluorobenzoic acid

実験手順

To 2,3-difluoro-benzoic acid (3 g) was added to a solution of chlorosulfonic acid and the reaction mixture was stirred for 2 hours at room temperature. After such time, the reaction mixture was poured onto ice. The resulting solid precipitate was then filtered off and dried in vacuo to yield the title compound as a light grey solid (4.8 g, mp=109-114° C., MS (EI): 256.0 (M+) and was used directly in the next step without any further purification.

後処理

  1. additionAfter such time, the reaction mixture was poured onto ice
  2. filtrationThe resulting solid precipitate was then filtered off
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-1bd0c94df54c484aad321ce3f5b03f93
出典データセット
uspto-grants-2008_09
特許番号
US07427612B2

関連ノート

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