Dimethylformamide → 3,4,5-Trimethoxyphenylacetonitrile

HRID 327498

反応式

HRID 327498 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6]Cl.[C-]#N.[Na+].[CH3:18][N:19](C)C=O>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][C:18]#[N:19])[CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzene

生成物 1

HCID 258873,4,5-Trimethoxyphenylacetonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

3,4,5-trimethoxy benzyl chloride 7.0 g and sodium cyanide 6.3 g were dissolved into 50 ml of N,N-dimethylformamide and they were then stirred at 80° C. for 45 minutes. The temperature of the reactive liquid was then lowered down to the room temperature, 200 ml of water was added thereto and then extraction was made thrice by means of 100 ml of ethyl acetate.

後処理

  1. additionwas added
  2. extractionextraction

出典と根拠

ORDレコード
ord-952544069fad4375a8343463edfcc445
出典データセット
uspto-grants-1993_12
特許番号
US05273985

関連ノート

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