Sodium borohydride → 2-Cyclobutyl-4-thiazole methanol

HRID 327569

反応式

HRID 327569 の反応式
[BH4-].[Na+].C([O:5][C:6]([C:8]1[N:9]=[C:10]([CH:13]2[CH2:16][CH2:15][CH2:14]2)[S:11][CH:12]=1)=O)C>C(O)C>[CH:13]1([C:10]2[S:11][CH:12]=[C:8]([CH2:6][OH:5])[N:9]=2)[CH2:14][CH2:15][CH2:16]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 54513950Ethyl 2-cyclobutylthiazole-4-carboxylate

生成物 1

HCID 539708732-Cyclobutyl-4-thiazole methanol収率 101.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium borohydride (2.3 g) was added in portions over a 10 min period to an ice cold solution of 6.3 g of 2-cyclobutyl-4-thiazolecarboxylic acid ethyl ester in 100 ml of ethyl alcohol. The ice bath was removed and the reaction mixture stirred at room temperature for 30 hr during which an additional 0.46 g of sodium borohydride was added. The reaction mixture was then diluted with 200 ml of ice water and extracted with ethyl ether. The combined extracts were washed with water, dried (MgSO4) and condensed in vacuo to yield 5.1 g of 2-cyclobutyl-4-thiazole methanol as an oil.

後処理

  1. customThe ice bath was removed
  2. additionwas added
  3. additionThe reaction mixture was then diluted with 200 ml of ice water
  4. extractionextracted with ethyl ether
  5. washThe combined extracts were washed with water
  6. customdried
  7. custom(MgSO4) and condensed in vacuo

出典と根拠

ORDレコード
ord-a162371cebec4ca8b6fc1fcf978e3bbe
出典データセット
uspto-grants-1993_12
特許番号
US05273986

関連ノート

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