Toluene → (E)-5-methoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid
反応式
[CH:1]1([C:5]2[N:6]=[C:7](/[CH:10]=[CH:11]/[C:12]3[CH:13]=[C:14]([NH2:18])[CH:15]=[CH:16][CH:17]=3)[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.CO[C:21]1[CH:32]=[C:25]2[CH2:26][C:27]([O:29][C:30](=[O:31])[C:24]2=[CH:23][CH:22]=1)=[O:28].C1(C)C=CC=CC=1.[O:40]1CCC[CH2:41]1>>[CH3:41][O:40][C:22]1[CH:21]=[CH:32][C:25]([CH2:26][C:27]([NH:18][C:14]2[CH:15]=[CH:16][CH:17]=[C:12](/[CH:11]=[CH:10]/[C:7]3[S:8][CH:9]=[C:5]([CH:1]4[CH2:4][CH2:3][CH2:2]4)[N:6]=3)[CH:13]=2)=[O:28])=[C:24]([CH:23]=1)[C:30]([OH:29])=[O:31]参加物
5
実験手順
A solution of 0.4 g of (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine, 0.4 g of 5-methoxyhomophthalic anhydride, 50 ml of toluene and 10 ml of tetrahydrofuran was heated to reflux for 0.5 hr. The solvents were removed by rotary evaporation and the residual materials were triturated with ethanol to yield (E)-5-methoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid, m.p. 190°-191° C.
後処理
- temperatureto reflux for 0.5 hr
- customThe solvents were removed by rotary evaporation
- customthe residual materials were triturated with ethanol
出典と根拠
- ORDレコード
- ord-cec2533c5c6a4d43932e7a95188f8870
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05273986
反応ノート
読み込み中…