Hydrochloric Acid → 3-(Benzothiazol-2-yl)-4-Phenyl-2-(5H) Furanone

HRID 327757

反応式

HRID 327757 の反応式
[C:1]([O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O)(=[O:3])[CH3:2].[S:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]=[C:15]1CC([O-])=O.[OH-].[Na+].Cl>CO>[S:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]=[C:15]1[C:2]1[C:1](=[O:3])[O:4][CH2:5][C:6]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 222851Ethanone, 2-(acetyloxy)-1-phenyl-HCID 7128533alpha-(Benzothiazol-2-yl)-acetate

生成物 1

HCID 541813413-(Benzothiazol-2-yl)-4-Phenyl-2-(5H) Furanone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

A solution of 2-acetoxyacetophenone (from Example 1) (8.9 g, 0.05M) and α-(benzothiazol-2-yl)-acetate (from Example 3) dissolved in methanol (40 mL) by stirring at room temperature was treated at room temperature with a solution prepared by dissolving sodium hydroxide pellets (2.5 g) in methanol (30 mL) by stirring. A slight exothermic reaction was observed. After being stirred at about room temperature for about 1.0 hour, the reaction mixture was acidified to a pH of about 4 by the dropwise addition of concentrated HCl. The product which was a dark brown colored semi-crystalline mass was washed by decantation and dried in air (yield--12.0 g (81.9% of the theoretical yield). Mass spectrometry indicated that the product largely consisted of the following desired compound: ##STR16##

後処理

  1. additionwas treated at room temperature with a solution
  2. customprepared
  3. stirringby stirring
  4. customA slight exothermic reaction
  5. stirringAfter being stirred at about room temperature for about 1.0 hour
  6. washwas washed by decantation
  7. customdried in air (
  8. customyield--12.0 g (81.9% of the
  9. customtheoretical yield)

出典と根拠

ORDレコード
ord-6a524c00b0354527b91f0643f335c8bc
出典データセット
uspto-grants-1993_12
特許番号
US05274072

関連ノート

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