Isopropanol → 4-Cyclopropylmethoxy-2-chloromethylpyridine hydrochloride

HRID 327778ノート

反応式

HRID 327778 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([CH2:12]O)[CH:7]=2)[CH2:3][CH2:2]1.O=S(Cl)[Cl:16].C(O)(C)C>C(Cl)Cl>[ClH:16].[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][Cl:16])[CH:7]=2)[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 3776IsopropanolHCID 24386Thionyl ChlorideHCID 108450754-Cyclopropylmethoxy-2-hydroxymethylpyridine

生成物 1

HCID 193909394-Cyclopropylmethoxy-2-chloromethylpyridine hydrochloride収率 84.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

4-cyclopropylmethoxy-2-hydroxymethylpyridine (93% pure) (0.9 g 0.0046 mol) was dissolved in methylene chloride (10 ml) and cooled to 0° C. SOCl2 (0.5 ml, 0.0069 mol) in methylene chloride (5 ml) was added dropwise at 0° C. and the reaction mixture was stirred 15 min at room temperature. Isopropanol (0.5 ml) was added and the mixture was evaporated giving the desired product (0.68 g, 78%). NMR data is given below.

後処理

  1. customthe mixture was evaporated

出典と根拠

ORDレコード
ord-7484a3259ed946a28b458a8b75b3bd39
出典データセット
uspto-grants-1993_12
特許番号
US05274099

反応ノート

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