Salicylaldehyde → 2-[[5-(Acetyloxy)pentyl]oxy]benzaldehyde

HRID 327952

反応式

HRID 327952 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]([OH:9])=[C:5]([CH:7]=[O:8])[CH:6]=1.[C:10]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]Br)(=[O:12])[CH3:11].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[C:10]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:9][C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=1[CH:7]=[O:8])(=[O:12])[CH3:11]

参加物

5

反応物 3

HCID 6998SalicylaldehydeHCID 11430Potassium CarbonateHCID 851405-Bromopentyl acetate

生成物 1

HCID 199221122-[[5-(Acetyloxy)pentyl]oxy]benzaldehyde収率 43,549.398%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 12.2 g (0.1 mmol) of salicyladehyde, 23 g (0.11 mol) of 5-bromopentyl acetate, 44.2 g (0.3 mol) of anhydrous, granular potassium carbonate, and 700 mL of acetonitrile was stirred and refluxed for 20 hr. After being cooled, the resulting mixture was filtered with suction and the solids were washed well with ether. The filtrate and washes were combined and concentrated in vacuo giving a yellow oil which was purified by flash chromatography on silica gel, eluting with 4:1 hexane-ether. There was obtained 10.9 g (43.6%) of 2-[[5-(acetyloxy)pentyl]oxy]benzaldehyde as an oil.

後処理

  1. temperaturerefluxed for 20 hr
  2. temperatureAfter being cooled
  3. filtrationthe resulting mixture was filtered with suction
  4. washthe solids were washed well with ether
  5. concentrationconcentrated in vacuo
  6. customgiving a yellow oil which
  7. customwas purified by flash chromatography on silica gel
  8. washeluting with 4:1 hexane-ether

出典と根拠

ORDレコード
ord-96c76a38e9b4404eaa89b1c139393c2e
出典データセット
uspto-grants-1993_12
特許番号
US05273999

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