2-Chloroethyl isocyanate → N-(6-Bromo-2-pyridinyl)-N'-(2-chloroethyl)urea
反応式
[Br:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][CH:3]=1.[Cl:9][CH2:10][CH2:11][N:12]=[C:13]=[O:14]>C1COCC1>[Br:1][C:2]1[N:7]=[C:6]([NH:8][C:13]([NH:12][CH2:11][CH2:10][Cl:9])=[O:14])[CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of 6-bromo-2-pyridinamine (1 g, 5.78 mmol) in anh. THF (25 mL), at r.t., under N2, was added 1-chloro-2-isocyanatoethane (1.2 mL, 2.5 eq) and the reaction mixture was stirred at r.t. for 18 hr. The crude mixture was partitioned between CH2Cl2 and water. The phases were separated and the organic layer was dried over anh. Na2SO4. The solids were filtered and the solvent evaporated to give the title compound (1.06 g, 66%) which was used in the next step without further purification.
後処理
- customThe crude mixture was partitioned between CH2Cl2 and water
- customThe phases were separated
- dry with materialthe organic layer was dried over anh. Na2SO4
- filtrationThe solids were filtered
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-a57cf86785af40228e02713709f17dc7
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07427630B2
反応ノート
読み込み中…