Thionyl Chloride → HCID 21443926、化合物
反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=O)=[CH:6][CH:5]=1)(=[NH:3])[NH2:2].S(Cl)([Cl:16])=O>C1C=CC=CC=1.CN(C)C=O>[ClH:16].[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([Cl:16])=[O:13])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2]参加物
5
実験手順
5.35 g of 4-amidinophenylacetic acid (M.p. 295° to 297° C, decomposition) were suspended in 45 ml of anhydrous benzene. Two drops of dimethylformamide and 17.9 g of thionyl chloride were added and the whole was heated for 11/2 hours under reflux. After cooling, the solid product was filtered off with suction, washed with anhydrous benzene and dried under reduced pressure. 6.9 g of 4-amidino-phenylacetyl chloride-hydrochloride melting at 174° to 177° C (decomposition) were obtained.
後処理
- temperaturethe whole was heated for 11/2 hours
- temperatureunder reflux
- temperatureAfter cooling
- filtrationthe solid product was filtered off with suction
- washwashed with anhydrous benzene
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-d93d65c20ae7453291def8277cf8f509
- 出典データセット
- uspto-grants-1977_04
- 特許番号
- US04016159
反応ノート
読み込み中…