Thionyl Chloride → HCID 178479372、化合物
反応式
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][CH:6]=1)[C:2]([NH2:4])=[NH:3].S(Cl)([Cl:17])=O>>[ClH:17].[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([Cl:17])=[O:14])=[CH:7][CH:6]=1)[C:2]([NH2:4])=[NH:3]参加物
3
反応条件
- 温度
- 0 °C
実験手順
21 g of 4-guanidino-phenylacetic acid were added to 200 ml of thionyl chloride that had been cooled to 0° C. After 15 minutes at 0° C, the whole was stirred for 15 minutes at room temperature, the product as precipitated with 500 ml of anhydrous ether, filtered off with suction, washed with anhydrous ether and dried under reduced pressure. 24.7 g of 4-guanidino-phenylacetyl chloride hydrochloride melting at 127° to 130° C were obtained.
後処理
- customthe product as precipitated with 500 ml of anhydrous ether
- filtrationfiltered off with suction
- washwashed with anhydrous ether
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-e2786caefb934e4e9c5785a27b2238f4
- 出典データセット
- uspto-grants-1977_04
- 特許番号
- US04016159
反応ノート
読み込み中…