Pyridine → ZR 2646

HRID 328152ノート

反応式

HRID 328152 の反応式
N1C=CC=CC=1.[C:7](Cl)(=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9].Cl.N1C=CC=CC=1.[CH2:21]([O:23][C:24]([C:26]1[CH:37]=[CH:36][C:29]([O:30][CH2:31][CH:32]([OH:35])[CH2:33][CH3:34])=[CH:28][CH:27]=1)=[O:25])[CH3:22]>>[C:7]([O:35][CH:32]([CH2:33][CH3:34])[CH2:31][O:30][C:29]1[CH:36]=[CH:37][C:26]([C:24]([O:23][CH2:21][CH3:22])=[O:25])=[CH:27][CH:28]=1)(=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9]

参加物

5

反応物 4

HCID 1049PyridineHCID 62493Pivaloyl chlorideHCID 10176127Pyridinium chlorideHCID 21444117Ethyl 4-(2-hydroxybutoxy)benzoate

生成物 1

HCID 162792ZR 2646収率 89%

実験手順

In pyridine (10ml) 1.2 g (5 mmol) of 1-(p-ethoxycarbonyl-phenoxy)-butan- 2-ol was dissolved and to this solution was gradually added 0.6 g (5 mmol) of pivaloyl chloride cooling in an ice bath. The mixture was stirred at room temperature for 3 hours after the addition was completed. During the course of the reaction pyridine hydrochloride precipitated. The reaction mixture was then poured in ice water and extracted with ethyl acetate. The extract was washed with water, dried, and concentrated to afford 1.6g of 1-(p-ethoxycarbonyl-phenoxy)-butan-2-ol pivalate (compound No. 1) in a yield of 89% as a light yellow viscous oily substance.

後処理

  1. additionafter the addition
  2. customprecipitated
  3. additionThe reaction mixture was then poured in ice water
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with water
  6. customdried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-0f22a9d3d5004617b51f20e6cd35464c
出典データセット
uspto-grants-1977_04
特許番号
US04016186

反応ノート

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