Nitric Acid → 2-(4-Methoxy-3-nitrophenyl)propanoic acid

HRID 328164

反応式

HRID 328164 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[N+:14]([O-])([OH:16])=[O:15]>S(=O)(=O)(O)O>[N+:14]([C:8]1[CH:7]=[C:6]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])[CH:5]=[CH:4][C:3]=1[O:2][CH3:1])([O-:16])=[O:15]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 257576p-Methoxyphenylpropionic acid

生成物 1

HCID 214441642-(4-Methoxy-3-nitrophenyl)propanoic acid

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

5.23g of 2-(4-methoxyphenyl)propionic acid was added gradually under cooling in a mixture of 27.5g of nitric acid and 19.9g of sulfuric acid. After the mixture was stirred at -10° C to -5° C for 6 hours, the mixture was poured into ice-water. The thus obtained oily substance was extracted with ethyl acetate. The extract was dried over magnesium sulfate and distilled off. The residue was purified by means of silica gel chromatography to give the object compound having m.p. 89° - 90° C in a yield of 5.0g (76%).

後処理

  1. extractionThe thus obtained oily substance was extracted with ethyl acetate
  2. dry with materialThe extract was dried over magnesium sulfate
  3. distillationdistilled off
  4. customThe residue was purified by means of silica gel chromatography
  5. customto give the object compound

出典と根拠

ORDレコード
ord-b476517894b34ed79c4361eb6510c9fe
出典データセット
uspto-grants-1977_04
特許番号
US04016193

関連ノート

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