Nitric Acid → Methyl 2-(3-nitro-4-hydroxyphenyl)propionate

HRID 328169ノート

反応式

HRID 328169 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:13])[C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.[N+:14]([O-])([OH:16])=[O:15]>C(O)(=O)C>[N+:14]([C:7]1[CH:6]=[C:5]([CH:8]([CH3:13])[C:9]([O:11][CH3:12])=[O:10])[CH:4]=[CH:3][C:2]=1[OH:1])([O-:16])=[O:15]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 12549710Methyl 2-(4-hydroxyphenyl)propanoate

生成物 1

HCID 12872610Methyl 2-(3-nitro-4-hydroxyphenyl)propionate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

In a mixture of 18ml of nitric acid and 30ml of acetic acid 2.76g of methyl 2-(4-hydroxyphenyl)propionate was stirred at -10° to -20° C for 4 hours. The reaction mixture was poured into ice water and extracted with chloroform. The extract was washed with a sodium hydrogen carbonate solution and water and dried over magnesium sulfate. The chloroform was distilled off to give the desired compound in a yield of 2.35g (69%). The physical data of this compound coincided with those of the compound as described above.

後処理

  1. extractionextracted with chloroform
  2. washThe extract was washed with a sodium hydrogen carbonate solution and water
  3. dry with materialdried over magnesium sulfate
  4. distillationThe chloroform was distilled off

出典と根拠

ORDレコード
ord-937cac51896e418286af13e5cc3938e3
出典データセット
uspto-grants-1977_04
特許番号
US04016193

反応ノート

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