Formaldehyde → 3-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride

HRID 328184ノート

反応式

HRID 328184 の反応式
[Cl-:1].[CH:2]([N:4]([CH2:9][CH2:10][CH2:11][N+:12]([CH3:15])([CH3:14])[CH3:13])[CH2:5][CH2:6][CH2:7][OH:8])=O.C=O>C(O)=O>[ClH:1].[Cl-:1].[OH:8][CH2:7][CH2:6][CH2:5][N:4]([CH2:9][CH2:10][CH2:11][N+:12]([CH3:15])([CH3:14])[CH3:13])[CH3:2]

参加物

4

反応物 2

HCID 712FormaldehydeHCID 213163693-[N'-formyl-N'-(3-hydroxypropyl)amino]-N,N,N-trimethyl-1-propanaminium chloride

生成物 1

HCID 213163673-[N-(3-hydroxypropyl)methylamino]-N,N,N-trimethylpropan-1-aminium chloride hydrochloride

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

A mixture of 2 g. of 3-[N'-formyl-N'-(3-hydroxypropyl)amino]-N,N,N-trimethyl-1-propanaminium chloride 4 g. of 99% formic acid and 2 ml. of formalin is stirred and heated at 100° for 17 hours. To the cooled mixture is added 11 ml. of concentrated hydrochloric acid and the reaction mixture is concentrated under reduced pressure. The product is taken up in 35 ml. of 1 N hydrochloric acid and the solution is filtered and concentrated to dryness under reduced pressure yielding 3-[N'-(3-hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium chloride hydrochloride.

後処理

  1. additionA mixture of 2 g
  2. temperatureheated at 100° for 17 hours
  3. additionTo the cooled mixture is added 11 ml
  4. concentrationof concentrated hydrochloric acid and the reaction mixture is concentrated under reduced pressure
  5. filtrationof 1 N hydrochloric acid and the solution is filtered
  6. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-d9d42b07a44148eda82f8ac09fe1cb9a
出典データセット
uspto-grants-1977_04
特許番号
US04016209

反応ノート

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