1,1,2,2-Tetrachloroethylsulfenyl chloride → 6-propyl-1H-pyrimidin-4-one;hydrochloride

HRID 328199

反応式

HRID 328199 の反応式
S[C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([CH2:9][CH2:10][CH3:11])[N:3]=1.[Cl:12]C(Cl)(SCl)C(Cl)Cl>COCCOC>[ClH:12].[OH:8][C:6]1[CH:5]=[C:4]([CH2:9][CH2:10][CH3:11])[N:3]=[CH:2][N:7]=1

参加物

4

反応物 2

HCID 144531,1,2,2-Tetrachloroethylsulfenyl chlorideHCID 178439476HCID 178439476、化合物

生成物 1

HCID 1784394686-propyl-1H-pyrimidin-4-one;hydrochloride

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

To a slurry of 5.0 g (0.029 mol) of 2-mercapto-4-hydroxy-6-propyl pyrimidine in 50 ml of 1,2-dimethoxyethane was added 6.9 g (0.029 mol) of 1,1,2,2-tetrachloroethylsulfenyl chloride. The resulting mixture was heated at the reflux temperature for 10 minutes, and then filtered while still hot. The solvent was removed by evaporation under reduced pressure to give 8.8 g of 1,1,2,2-tetrachloroethylsulfenylmercapto)-4-hydroxy-6-propyl pyrimidine hydrochloride having a melting point of 142°-144° C. Analysis was as follows: %Cl, calc., 43.8, found 43.0; %S, calc. 15.8, found 15.5.

後処理

  1. temperatureThe resulting mixture was heated at the reflux temperature for 10 minutes
  2. filtrationfiltered while still hot
  3. customThe solvent was removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-96dae9673bb64a038e2e1928c5909d00
出典データセット
uspto-grants-1977_04
特許番号
US04016275

関連ノート

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