Hydrochloric Acid → HCID 86734627、化合物

HRID 328203ノート

反応式

HRID 328203 の反応式
[CH:1]1([N:7]2[CH:14]=[CH:13][C:11]([NH2:12])=[N:10][C:8]2=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:15]([NH:18][C:19]1[CH:28]=[CH:27][C:22]([S:23](Cl)(=[O:25])=[O:24])=[CH:21][CH:20]=1)(=[O:17])[CH3:16].Cl.C1(C2(C=CC(C3N=CC=CN=3)(N)CC2=O)S(N)(=O)=O)CCCCC1>O.N1C=CC=CC=1>[C:15]([NH:18][C:19]1[CH:28]=[CH:27][C:22]([S:23]([NH:12][C:11]2[CH:13]=[CH:14][N:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[C:8](=[O:9])[N:10]=2)(=[O:25])=[O:24])=[CH:21][CH:20]=1)(=[O:17])[CH3:16]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8481N-Acetylsulfanilyl chlorideHCID 1930061-CyclohexylcytosineHCID 86734628HCID 86734628、化合物

生成物 1

HCID 86734627HCID 86734627、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1049Pyridine溶媒

実験手順

A mixture of 29.0 g. of 1-cyclohexylcytosine, 90 ml. of pyridine and 35.1 g. of N-acetylsulfanilyl chloride was stirred overnight, poured into 900 ml. of water, and acidified by addition of 80 ml. of concentrated hydrochloric acid. After several hours of vigorous stirring, the precipitated product solidified to yield 33.3 g. of N4 -acetyl-N1 -(1-cyclohexyl-1,2-dihydro-2-oxo-4-pyrimidinyl-sulfanilamide, m.p. 219°-234°. A sample purified by two recrystallizations from ethanol melted at 247°-250°.

後処理

  1. additionA mixture of 29.0 g
  2. additionpoured into 900 ml
  3. waitAfter several hours of vigorous stirring
  4. customto yield 33.3 g
  5. customA sample purified by two recrystallizations from ethanol melted at 247°-250°

出典と根拠

ORDレコード
ord-d9dabf4ceda741bb885d6cd5f6a6727f
出典データセット
uspto-grants-1977_04
特許番号
US04016267

反応ノート

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