Hydrazine hydrate (1:1) → 8-Hydroxy-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione

HRID 328322ノート

反応式

HRID 328322 の反応式
Cl.[OH:2][C:3]1[C:4]([C:20]([OH:22])=O)=[C:5]([C:15](OCC)=[O:16])[CH:6]=[N:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O.[NH2:24][NH2:25]>C(O)C>[OH:2][C:3]1[C:4]2[C:20](=[O:22])[NH:25][NH:24][C:15](=[O:16])[C:5]=2[CH:6]=[N:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 131710706HCID 131710706、化合物

生成物 1

HCID 123246328-Hydroxy-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2 g. ethyl 5-hydroxy-6-phenylpyridine3,4-dicarboxylate. hydrochloride, 40 ml ethanol and 4 ml hydrazine hydrate was refluxed for 4 hours. After cooling, the pale yellow crystals were recovered by filtration, suspended in 20 ml of water and made acid with dilute hydrochloric acid. The crystals were recovered by filtration, rinsed with water and dried. The procedure provided 1.2 g of 8-hydroxy-7-phenylpyrido[3,4-d]pyridazine-1,4-(2H,3H)-dione, melting point: more than 300° C.

後処理

  1. additionA mixture of 2 g
  2. temperatureAfter cooling
  3. filtrationthe pale yellow crystals were recovered by filtration
  4. filtrationThe crystals were recovered by filtration
  5. washrinsed with water
  6. customdried

出典と根拠

ORDレコード
ord-1cffaf3e3bae4354b076dead8e515b99
出典データセット
uspto-grants-1977_04
特許番号
US04017490

反応ノート

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