Thiabendazole → 1-(2-Ethyl-1-butoxycarbonyl)-2-(4-thiazolyl)-benzimidazole

HRID 328336ノート

反応式

HRID 328336 の反応式
Cl[C:2]([O:4][CH2:5][CH:6]([CH2:9][CH3:10])[CH2:7][CH3:8])=[O:3].[S:11]1[CH:15]=[C:14]([C:16]2[NH:17][C:18]3[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=3[N:20]=2)[N:13]=[CH:12]1>N1C=CC=CC=1>[CH2:7]([CH:6]([CH2:9][CH3:10])[CH2:5][O:4][C:2]([N:20]1[C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[N:17]=[C:16]1[C:14]1[N:13]=[CH:12][S:11][CH:15]=1)=[O:3])[CH3:8]

参加物

4

反応物 2

HCID 5430ThiabendazoleHCID 544120422-Ethylbutyl carbonochloridate

生成物 1

HCID 214417551-(2-Ethyl-1-butoxycarbonyl)-2-(4-thiazolyl)-benzimidazole

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

17.9 G (0.108 moles) of 2-ethyl-1-butyl chloroformate is added dropwise with protection from moisture to a stirred suspension of 21.7 (0.108 moles) of 2-(4-thiazolyl)-benzimidazole in 150 ml. of pyridine. The addition is carried out over a period of 35 minutes after which the reaction mixture is stirred overnight at room temperature. The reaction mixture is filtered and the filtrate evaporated to dryness in vacuo. The gummy residue is treated with 250 ml. of methylene chloride, filtered and washed twice with 250 ml. of 0.25 N-hydrochloric acid containing ice and 200 ml. of saturated sodium bicarbonate solution. The methylene chloride is dried and evaporated to dryness in vacuo affording 23.8 g. (67%) of a yellow-orange residual oil which is purified by column chromatography, the extract of which thin layer chromatography demonstrates to be pure 1-(2-ethyl-1-butoxycarbonyl)-2-(4-thiazolyl)-benzimidazole.

後処理

  1. additionThe addition
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate evaporated to dryness in vacuo
  4. additionThe gummy residue is treated with 250 ml
  5. filtrationof methylene chloride, filtered
  6. washwashed twice with 250 ml
  7. additionof 0.25 N-hydrochloric acid containing ice and 200 ml
  8. dry with materialThe methylene chloride is dried
  9. customevaporated to dryness in vacuo
  10. customaffording 23.8 g
  11. custom(67%) of a yellow-orange residual oil which is purified by column chromatography
  12. extractionthe extract of which thin layer chromatography

出典と根拠

ORDレコード
ord-ac5f9685b5b74b0bac8f497e48bb38ee
出典データセット
uspto-grants-1977_04
特許番号
US04017505

反応ノート

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