Acetone → 1-Fluoro-4-(prop-2-en-1-yloxy)benzene
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH2:9](Br)[CH:10]=[CH2:11].C(=O)([O-])[O-].[K+].[K+].CC(C)=O>O>[CH2:11]([O:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[CH:10]=[CH2:9]参加物
6
実験手順
A mixture of 336.3 parts of 4-fluorophenol, 417.5 parts of allyl bromide, 420 parts of potassium carbonate and 480 parts of acetone is stirred and refluxed for 8 hours. After cooling to room temperature, 2250 parts of water are added. The aqueous layer is separated and extracted twice with ether. The combined extracts are washed successively twice with sodium hydroxide solution 10% and twice with sodium chloride solution, dried over potassium carbonate, filtered and evaporated. The oily residue is distilled in vacuo, yielding 381.8 parts of 4-allyloxy-fluorobenzene; bp. 93° C at 23 mm. pressure; nD20 : 1.4950; d2020 : 1.070.
後処理
- temperaturerefluxed for 8 hours
- customThe aqueous layer is separated
- extractionextracted twice with ether
- washThe combined extracts are washed successively twice with sodium hydroxide solution 10% and twice with sodium chloride solution
- dry with materialdried over potassium carbonate
- filtrationfiltered
- customevaporated
- distillationThe oily residue is distilled in vacuo
出典と根拠
- ORDレコード
- ord-647e4a60349f4ef8aa0150ae4f015196
- 出典データセット
- uspto-grants-1977_04
- 特許番号
- US04017631
反応ノート
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