Phosphorus sulfide (P2S5) → HCID 9838314、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11](=O)[CH2:10][N:9]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:21]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11](=[S:21])[CH2:10][N:9]=1参加物
3
実験手順
A mixture of 1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one [Sternbach et al., J. Org. Chem. 27, 3788 (1962)] and P2S5 can be reacted in the same manner as in preparation I to produce 1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione. This latter compound can then be substituted in the procedure of Exmple 1 to produce 6-(o-fluorophenyll)-1methyl-4H-s-triazolo[4,3-a] [1,4] benzodiazepine.
後処理
- customcan be reacted in the same manner as in preparation I
出典と根拠
- ORDレコード
- ord-f0bbb311e87e474b9c0e21fdcd73aab7
- 出典データセット
- uspto-grants-1977_04
- 特許番号
- US04018788
反応ノート
読み込み中…