Isopropylamine → 3-Isopropylaminomethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid, ethyl ester

HRID 328806ノート

反応式

HRID 328806 の反応式
O[CH:2]=[C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([O:16][CH3:17])=[C:9]([O:14][CH3:15])[CH:10]=2)[N:5]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:4]1[CH3:23].[CH:24]([NH2:27])([CH3:26])[CH3:25]>C1C=CC=CC=1>[CH:24]([NH:27][CH:2]=[C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([O:16][CH3:17])=[C:9]([O:14][CH3:15])[CH:10]=2)[N:5]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:4]1[CH3:23])([CH3:26])[CH3:25]

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 70638946Racemic Ethyl 6,7-Dimethoxy-3-hydroxymethylene-2-methyl-4-oxo-1,2,3,4-tetrahydroquinoline-1-carboxylate

生成物 1

HCID 867338853-Isopropylaminomethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid, ethyl ester

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A solution of 3.2 g. of 3-hydroxymethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid, ethyl ester in 30 ml. of benzene containing 650 mg. of isopropylamine is allowed to stir at room temperature for 48 hrs. The reaction solution is concentrated to give 4 g. of a yellow foam which could not be induced to crystallize.

後処理

  1. concentrationThe reaction solution is concentrated
  2. customto give 4 g
  3. customto crystallize

出典と根拠

ORDレコード
ord-ce3cb90e9ecd4317b781180862a6e00c
出典データセット
uspto-grants-1977_04
特許番号
US04018758

反応ノート

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