2-Methoxyethylamine → 3-Methoxyethylaminomethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid, ethyl ester

反応式

O[CH:2]=[C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([O:16][CH3:17])=[C:9]([O:14][CH3:15])[CH:10]=2)[N:5]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:4]1[CH3:23].[CH3:24][O:25][CH2:26][CH2:27][NH2:28]>>[CH3:24][O:25][CH2:26][CH2:27][NH:28][CH:2]=[C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([O:16][CH3:17])=[C:9]([O:14][CH3:15])[CH:10]=2)[N:5]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:4]1[CH3:23]

参加物

反応物 2

HCID 80182-Methoxyethylamine

HCID 70638946Racemic Ethyl 6,7-Dimethoxy-3-hydroxymethylene-2-methyl-4-oxo-1,2,3,4-tetrahydroquinoline-1-carboxylate

生成物 1

HCID 1317104433-Methoxyethylaminomethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid, ethyl ester

実験手順

The procedure of Example 13 is repeated, starting with 3.21 g. of 3-hydroxymethylene-6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid, ethyl ester and 890 mg. of methoxyethylamine in 30 ml., to give 1.5 g. of the crude product as a yellow oil.

後処理

custom, to give 1.5 g

出典と根拠

ORDレコード: ord-8f3812ad3a924e34ae21e7293645becf
出典データセット: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04018758

反応ノート

読み込み中…