1-(5-Methoxy-2-nitro-phenyl)-piperidine → HCID 69307727、化合物

HRID 32888

反応式

HRID 32888 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:15]([O-])=O)=[C:7]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:8]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:15])=[C:7]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:8]=1

参加物

4

反応物 1

HCID 693104281-(5-Methoxy-2-nitro-phenyl)-piperidine

生成物 1

HCID 69307727HCID 69307727、化合物収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1-(5-methoxy-2-nitro-phenyl)-piperidine (80 mg, 0.33 mmol, as prepared in the previous step) was stirred with 55 mg of 5% Pd—C in MeOH (4 mL) under H2 balloon pressure for 2 h. The reaction was filtered through Celite and concentrated in vacuo to afford 67 mg (98%) of the title compound as a reddish solid, which was used immediately without further purification. Mass spectrum (ESI, m/z): Calcd. for C12H18N2O, 207.1 (M+H), found 207.2.

後処理

  1. filtrationThe reaction was filtered through Celite
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e30b55c16b3344b4aaa2732f6de7ee42
出典データセット
uspto-grants-2008_09
特許番号
US07427683B2

関連ノート

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