1-(2-Methyl-6-nitrophenyl)piperidine → 3-Methyl-2-(1-piperidinyl)aniline
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>[Pd]>[CH3:1][C:2]1[C:3]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4]([NH2:8])[CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
Using a procedure similar to Example 3, step (c), 1-(2-methyl-6-nitro-phenyl)-piperidine (74 mg, 0.38 mmol, as prepared in the previous step) was stirred with 5% Pd—C (50 mg) under H2 to afford 66 mg (91%) of the title compound as an oil. Mass spectrum (ESI, m/z): Calcd. for C12H18N2, 191.1 (M+H), found 191.1.
後処理
- customas prepared in the previous step)
出典と根拠
- ORDレコード
- ord-94a17360d02d4a83b6358d68d467f9a1
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07427683B2
反応ノート
読み込み中…