2,6-Dichlorobenzyl chloride → 2-(2,6-dichlorophenylmethylthio)pyridine N-oxide

HRID 329148

反応式

HRID 329148 の反応式
[SH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[O-:8].[Na].[Cl:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:12]=1[CH2:13]Cl>C(O)C>[Cl:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:12]=1[CH2:13][S:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[O-:8]

参加物

5

反応物 3

HCID 748322,6-Dichlorobenzyl chlorideHCID 5360545SodiumHCID 178526253HCID 178526253、化合物

生成物 1

HCID 124315032-(2,6-dichlorophenylmethylthio)pyridine N-oxide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 37 gms (0.1 mole) of (40% solution) 2-mercaptopyridine N-oxide, sodium salt and 19.5 gms (0.1 mole) 2,6-dichlorobenzylchloride in 200 ml ethanol is warmed to 65° for thirty minutes, cooled and filtered. The filter cake is washed thoroughly with water and finally with 40 ml of acetone. Vacuum drying of the cake yields 25.3 gms (92% theory) of product, 2-(2,6-dichlorophenylmethylthio)pyridine N-oxide. Melting point 240° - 241° C. Structure confirmed by IR.

後処理

  1. temperatureis warmed to 65° for thirty minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. washThe filter cake is washed thoroughly with water and finally with 40 ml of acetone
  5. customVacuum drying of the cake

出典と根拠

ORDレコード
ord-4c025561db1443c794b55ff51b53514b
出典データセット
uspto-grants-1977_04
特許番号
US04019893

関連ノート

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