Hydrochloric Acid → 2-[(Trifluoromethyl)sulfanyl]benzoic acid
反応式
C([O:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11][C:12]([F:15])([F:14])[F:13])C.[OH-].[Na+].Cl>C(O)C>[F:14][C:12]([F:13])([F:15])[S:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:4]([OH:16])=[O:3]参加物
5
実験手順
A solution of 5.0 g. of ethyl-o-(trifluoromethylthio)benzoate, 30 ml. of ethanol and 20 ml. of 10% sodium hydroxide was refluxed for 1.5 hrs. After cooling, the solution was acidified with 6N hydrochloric acid. The product was collected by filtration, dried, and recrystallized from a mixture of 60% hexane-40% benzene to give o-(trifluoromethylthio)benzoic acid, m.p. 119°-121° .
後処理
- temperatureAfter cooling
- filtrationThe product was collected by filtration
- customdried
- customrecrystallized from a mixture of 60% hexane-40% benzene
出典と根拠
- ORDレコード
- ord-fe42694234264620a018a45ad173d911
- 出典データセット
- uspto-grants-1977_04
- 特許番号
- US04020169
反応ノート
読み込み中…