Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

HRID 329341

反応式

HRID 329341 の反応式
C(C1C=NC(C2C=CC([OH:23])=CC=2)=NC=1)CCCCCCCCC.C([C@H]1CC[C@H](C(O)=O)CC1)CCCC.[CH:38]1([N:44]=[C:45]=[N:46][CH:47]2[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]2)[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1>ClCCl>[CH:47]1([NH:46][C:45]([NH:44][CH:38]2[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)=[O:23])[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 135585902Phenol, 4-(5-decyl-2-pyrimidinyl)-HCID 178444557HCID 178444557、化合物

生成物 1

HCID 4277N,N'-Dicyclohexylurea

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 35.4 g of 4-(5-decylpyrimidin-2-yl)phenol, 22.5 g of trans-4-pentylcyclohexanecarboxylic acid and 23.4 g of N,N'-dicyclohexylcarbodiimide in 600 ml of dichloromethane is stirred at 20° C. for 12 hours. The N,N'-dicyclohexylurea formed is filtered off, and the filtrate is chromatographed over 5 kg of silica gel using dichloromethane. The product-containing fraction gives 21.5 g of colorless crystals after recrystallization from n-hexane.

出典と根拠

ORDレコード
ord-52fde18c50ee408583b6415095779c69
出典データセット
uspto-grants-1990_01
特許番号
US04891151

関連ノート

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