2-Chloroethanol → Biphenol-diethanol

HRID 329346

反応式

HRID 329346 の反応式
[C:1]1([OH:14])[C:2]([C:7]2[C:8]([OH:13])=[CH:9][CH:10]=[CH:11][CH:12]=2)=[CH:3][CH:4]=[CH:5][CH:6]=1.[OH-].[Na+].Cl[CH2:18][CH2:19][OH:20].[CH2:21]([OH:23])[CH3:22]>>[C:8]1([OH:13])[C:7]([C:2]2[C:1]([OH:14])=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:12]([CH2:22][CH2:21][OH:23])[C:11]([CH2:18][CH2:19][OH:20])=[CH:10][CH:9]=1

参加物

5

反応物 4

HCID 342-ChloroethanolHCID 702Ethanol2 回HCID 14798Sodium HydroxideHCID 15731(1,1'-Biphenyl)-2,2'-diol

生成物 1

HCID 19996287Biphenol-diethanol

実験手順

To biphenol (0.5 mole) and 200 milliliters of absolute ethanol and sodium hydroxide (1.1 millimole) at 80° C. was added dropwise a solution of 2-chloroethanol (1 mole) in 50 milliliters of absolute ethanol. The mixture was refluxed for 48 hours, and then filtered hot and washed twice with boiling ethanol (100 milliliters). Recrystallization from boiling water provided the precursor product biphenol-diethanol, 80 to 85 percent yield of colorless crystals. The melting point for this product was 210 to 211° C.

後処理

  1. temperatureThe mixture was refluxed for 48 hours
  2. filtrationfiltered hot
  3. washwashed twice with boiling ethanol (100 milliliters)
  4. customRecrystallization

出典と根拠

ORDレコード
ord-3be03b6fed26496e874c1462685d7a91
出典データセット
uspto-grants-1990_01
特許番号
US04891293

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