Dichloromethane → 3-(2-Thienyl)-propanoic acid chloride

HRID 329389

反応式

HRID 329389 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=O.C(Cl)[Cl:12]>C(Cl)(=O)C(Cl)=O.CN(C)C=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([Cl:12])=[O:10]

参加物

5

反応物 2

HCID 6344DichloromethaneHCID 7031693-(2-Thienyl)propanoic acid

生成物 1

HCID 149601613-(2-Thienyl)-propanoic acid chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 65578Oxalyl chloride溶媒

実験手順

To a solution of 5.0 g (0.032 mol) of 3-(2-thienyl)propionic acid in 2 ml of methylene chloride and 25 ml of oxalyl chloride was added three drops of N,N-dimethylformamide slowly. Following evolution of the gas the reaction mixture was concentrated under vacuum and 20 ml of hexane was added to the residue. The resulting mixture was filtered and the filtrate was concentrated under vacuum. The resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction.

後処理

  1. concentrationwas concentrated under vacuum and 20 ml of hexane
  2. additionwas added to the residue
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate was concentrated under vacuum
  5. customThe resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction

出典と根拠

ORDレコード
ord-2e3424e2761c4ae3b61e15296de10c0d
出典データセット
uspto-grants-1990_01
特許番号
US04891379

関連ノート

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