Hydrochloric Acid → 4-Chloro-6-cyclopropyl-1,3,5-triazin-2-amine
反応式
[Na].[C:2]([NH:4][C:5]([CH:9]1[CH2:11][CH2:10]1)=[N:6][C:7]#[N:8])#[N:3].[ClH:12].CCCCCC>CC(=O)CC>[NH2:8][C:7]1[N:3]=[C:2]([Cl:12])[N:4]=[C:5]([CH:9]2[CH2:11][CH2:10]2)[N:6]=1参加物
6
反応条件
- 温度
- 10 °C
実験手順
33 g of the sodium salt of N,N'-dicyano-cyclopropanecarbamidine (crude product) is suspended in 100 ml butanone. A solution of 20 g HCl in 400 ml butanone is dropped under stirring into this solution at 10° C. After the addition has been completed it is stirred for 1 h at ambient temperature. The reaction mixture is concentrated by evaporation and 200 ml of saturated aqueous NaHCO3 -solution and 300 ml diethylether are added. The organic phase is separated, washed, dried and concentrated by evaporation. One isolates 21 g of crude product which is treated with hexane to leave the pure title product.
後処理
- additionAfter the addition
- stirringis stirred for 1 h at ambient temperature
- concentrationThe reaction mixture is concentrated by evaporation and 200 ml of saturated aqueous NaHCO3 -solution and 300 ml diethylether
- additionare added
- customThe organic phase is separated
- washwashed
- customdried
- concentrationconcentrated by evaporation
- customOne isolates 21 g of crude product which
出典と根拠
- ORDレコード
- ord-9c52b814efe34122964a2622207880d0
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04891443
反応ノート
読み込み中…