Thiazole → 3-[7-(trans-3-Hexadecyloxytetrahydropyran-2-ylmethoxy)heptyl]thiazolium methanesulfonate

HRID 329497ノート

反応式

HRID 329497 の反応式
[CH3:1][S:2]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH2:14][C@H:15]1[C@H:20]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:19][CH2:18][CH2:17][O:16]1)(=[O:4])=[O:3].[S:38]1[CH:42]=[CH:41][N:40]=[CH:39]1>C1(C)C=CC=CC=1>[CH3:1][S:2]([O-:5])(=[O:4])=[O:3].[CH2:22]([O:21][C@@H:20]1[CH2:19][CH2:18][CH2:17][O:16][C@H:15]1[CH2:14][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][N+:40]1[CH:41]=[CH:42][S:38][CH:39]=1)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]

参加物

4

反応物 2

HCID 9256ThiazoleHCID 186371317-(trans-3-Hexadecyloxytetrahydropyran-2-ylmethoxy)heptyl methanesulfonate

生成物 1

HCID 186371263-[7-(trans-3-Hexadecyloxytetrahydropyran-2-ylmethoxy)heptyl]thiazolium methanesulfonate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

1.20 g of the methanesulfonate [prepared as described in step (a) above] and 1.56 ml of thiazole were dissolved in 3 ml of toluene, and the solution was stirrd on an oil bath kept at 70° C. for 5 days. At the end of this time, the mixture was allowed to cool, the solvent was distilled off under reduced pressure, and the residue was subjected to column chromatography through 40 g of silica gel. 0.741 g of the title compound was obtained as a viscous oil from the fractions eluted with a 60:35:5 by volume mixture of methylene chloride, methanol and water.

後処理

  1. customthe solution was stirrd on an oil bath
  2. temperatureto cool
  3. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-30aca703d20b46deb31f4950a25bb076
出典データセット
uspto-grants-1990_01
特許番号
US04891363

反応ノート

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