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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

Hydrochloric Acid → (3S,4R)-3-[(R)-1-hydroxyethyl]-4-[(R)-1-methyl-3-allyloxycarbonyl-2-oxopropyl]-2-azetidinone

HRID 329675

印刷プレビュー

反応式

HRID 329675 の反応式

[Si]([O:8][C@@H:9]([C@@H:11]1[C@@H:14]([C@@H:15]([CH3:25])[C:16](=[O:24])[CH2:17][C:18]([O:20][CH2:21][CH:22]=[CH2:23])=[O:19])[NH:13][C:12]1=[O:26])[CH3:10])(C(C)(C)C)(C)C.Cl.OP([O-])([O-])=O.[K+].[K+]>CO.C(OC(=O)C)C.O>[OH:8][C@@H:9]([C@@H:11]1[C@@H:14]([C@@H:15]([CH3:25])[C:16](=[O:24])[CH2:17][C:18]([O:20][CH2:21][CH:22]=[CH2:23])=[O:19])[NH:13][C:12]1=[O:26])[CH3:10]

参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 3

HCID 313Hydrochloric Acid

HCID 24450Potassium Phosphate, Dibasic

HCID 14138755(3S,4R)-3-[(R)-1-t-butyldimethylsilyloxyethyl]-4-[(R)-1-methyl-3-allyloxycarbonyl-2-oxopropyl]-2-azetidinone

生成物 1

HCID 14329059(3S,4R)-3-[(R)-1-hydroxyethyl]-4-[(R)-1-methyl-3-allyloxycarbonyl-2-oxopropyl]-2-azetidinone収率 89%

試薬・触媒・溶媒 3

HCID 887

Methanol

溶媒

HCID 962Water溶媒

HCID 8857Ethyl Acetate溶媒

実験手順

The keto ester 2 (1.047 g, 2.73 mmol) in methanol (12.3 ml) was treated with 6N HCl (1.37 ml, 8.22 mmol, 3 eg) and stirred 1 hour at room temperature. The solution was treated with 1M K2HPO4 (8.2 ml) and stirred a few minutes, then diluted with ethylacetate and water. The organic layer was separated, washed with 5% NaHCO3 and brine, dried with magnesium sulfate, filtered, and evaporated under vacuum to give the product 3 (0.653 g, 89%) as a clear oil.

後処理

stirringstirred a few minutes
customThe organic layer was separated
washwashed with 5% NaHCO3 and brine
dry with materialdried with magnesium sulfate
filtrationfiltered
customevaporated under vacuum

出典と根拠

ORDレコード: ord-0ae4142789d4493380135c93e84eb8fa
出典データセット: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04892869

反応ノート

読み込み中…

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