Water → 2-Methyl-3-(oxan-2-yloxy)propan-1-ol

HRID 329790

反応式

HRID 329790 の反応式
C([O:9][CH2:10][CH:11]([CH3:20])[CH2:12][O:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][O:15]1)(=O)C1C=CC=CC=1.[OH-].[Na+].O>CO>[CH3:20][CH:11]([CH2:12][O:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][O:15]1)[CH2:10][OH:9]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 147960471-Benzoyloxy-2-methyl-3-tetrahydropyranyloxypropane

生成物 1

HCID 122906532-Methyl-3-(oxan-2-yloxy)propan-1-ol収率 88.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-Benzoyloxy-2-methyl-3-tetrahydropyranyloxypropane (460 mg; 1.65 mmol) was dissolved in methanol (10 ml), and 1M sodium hydroxide solution (3 ml) and water (10 ml) were added thereto, and the resultant mixture was stirred at room temperature for 5 hours. The reaction mixture was extracted with ethyl acetate. The extracts were washed with water and dried over anhydrous magnesium sulfte. The solvent was removed by distillation, and the residue was purified by silica gel column chromatography using a mixture of ethyl acetate and benzene (1:4) to give 2-methyl-3-tetrahydropyranyloxy-1-propanol (254 mg; yield, 88%).

後処理

  1. extractionThe reaction mixture was extracted with ethyl acetate
  2. washThe extracts were washed with water
  3. dry with materialdried over anhydrous magnesium sulfte
  4. customThe solvent was removed by distillation
  5. customthe residue was purified by silica gel column chromatography
  6. additiona mixture of ethyl acetate and benzene (1:4)

出典と根拠

ORDレコード
ord-a1140472211246ecbe800f963780362d
出典データセット
uspto-grants-1990_01
特許番号
US04892961

関連ノート

読み込み中…