Sodium Carbonate → 2-Methoxy-3,4-dimethyl-2-cyclopenten-1-one
反応式
[CH3:1][O:2][CH2:3][C:4](=[O:15])[CH:5]([CH:10]([CH3:14])[C:11]([CH3:13])=O)C(OC)=O.C([O-])([O-])=O.[Na+].[Na+]>>[CH3:1][O:2][C:3]1[C:4](=[O:15])[CH2:5][CH:10]([CH3:14])[C:11]=1[CH3:13]参加物
3
実験手順
2.16 g (10 mmol) of methyl 4-methoxy-2-[1-methylacetonyl]-acetoacetate are held at reflux temperature for 2 hours with 21.2 ml (5 mmol) of 2.5% Na2CO3 solution. The reaction mixture is extracted 3 times with 25 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator to give 1.40 g (100%) or 2-methoxy-3,4-dimethyl-2-cyclopenten-1-one, content 96%.
後処理
- extractionThe reaction mixture is extracted 3 times with 25 ml of CH2Cl2 each time
- dry with materialThe combined organic phases are dried over magnesium sulphate
- concentrationconcentrated on a rotary evaporator
出典と根拠
- ORDレコード
- ord-ad4afb7e1b7d4657a997aac876e0c9f6
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04892966
反応ノート
読み込み中…