Sodium Carbonate → 3-Ethyl-2-methoxy-2-cyclopenten-1-one
反応式
[CH3:1][O:2][CH2:3][C:4](=[O:15])[CH:5]([CH2:10][C:11](=O)[CH2:12][CH3:13])C(OC)=O.C([O-])([O-])=O.[Na+].[Na+]>>[CH2:12]([C:11]1[CH2:10][CH2:5][C:4](=[O:15])[C:3]=1[O:2][CH3:1])[CH3:13]参加物
3
実験手順
21.60 g(100 mmol) of methyl 4-methoxy-2-(2-oxobutyl)-acetoacetate are held at reflux temperature for 8 hours with 212.0 g (50 mmol) of 2.5% Na2CO3 solution. After cooling the reaction mixture is extracted 3 times with 200 ml of CH2Cl2 each time. The combined organic phases are dried over magnesium sulphate and concentrated on a rotary evaporator. The crude product is column chromatographed over SiO2 and gives 4.08 g (29.1%) of 3-ethyl-2-methoxy-2-cyclopenten-1-one.
後処理
- temperatureAfter cooling the reaction mixture
- extractionis extracted 3 times with 200 ml of CH2Cl2 each time
- dry with materialThe combined organic phases are dried over magnesium sulphate
- concentrationconcentrated on a rotary evaporator
- customchromatographed over SiO2
出典と根拠
- ORDレコード
- ord-b8a97ca758a54388b57a2fd160ffb0f9
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04892966
反応ノート
読み込み中…