Sodium Hydroxide → Isopropyl 4-(3-chloro-2-thienyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]-pyridine-3-carboxylate
反応式
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=O.[NH2:9]/[C:10](/[CH3:18])=[CH:11]\[C:12]([O:14][CH:15]([CH3:17])[CH3:16])=[O:13].[OH-:19].[Na+]>CCO.Cl>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[C:11]([C:12]([O:14][CH:15]([CH3:17])[CH3:16])=[O:13])=[C:10]([CH3:18])[NH:9][C:10]2[CH2:18][O:19][C:12](=[O:13])[C:11]1=2参加物
6
実験手順
40 mmol of 3-chloro-thiophene-2-carbaldehyde, 40 mmol of 3-acetoxyacetoacetic acid ester and 40 mmol of isopropyl 3-aminocrotonate are boiled under reflux over NaOH in EtOH, alcoholic hydrochloric acid is then added and the mixture is boiled for 1 hour. It is concentrated and the residue is crystallized.
後処理
- additionis then added
- concentrationIt is concentrated
- customthe residue is crystallized
出典と根拠
- ORDレコード
- ord-aee42490354240fa80b740a939dfb9d0
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04894378
反応ノート
読み込み中…