Putrescine → 1-(4-Aminobutylamino)-4-methoxyanthracene-9,10-dione

HRID 330060

反応式

HRID 330060 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6].[CH3:7][O:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14](=[O:24])[C:13]=2[C:12](OC)=[CH:11][CH:10]=1>C(Cl)Cl>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:12]1[C:13]2[C:14](=[O:24])[C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:21](=[O:23])[C:22]=2[C:9]([O:8][CH3:7])=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 1045PutrescineHCID 2660541,4-Dimethoxyanthraquinone

生成物 1

HCID 133805781-(4-Aminobutylamino)-4-methoxyanthracene-9,10-dione収率 50.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1,4-Diaminobutane (1.65 g, 19 mmol) was added to a solution of 1,4-dimethoxyanthracene-9,10-dione (1.0 g, 3.7 mmol) in CH2Cl2 (700 ml). After seven, hours of irradiation, the solvent was removed and the residue chromatographed on silica gel. Starting material was eluted with CHCl3 and the product with 5% CH3OH in CHCl3. A purple solid (0.61 g, 50%) was obtained which was converted to the benzyloxycarbonyl derivative.

後処理

  1. customAfter seven, hours of irradiation
  2. customthe solvent was removed
  3. customthe residue chromatographed on silica gel
  4. washStarting material was eluted with CHCl3

出典と根拠

ORDレコード
ord-cb9650b945854228a55b0887a0509362
出典データセット
uspto-grants-1990_01
特許番号
US04894451

関連ノート

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